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I received my Bachelor’s Degree in Chemistry in 2009 and my Master’s Degree in Chemistry (Pharmaceutical Chemistry Module) in 2011 at Eötvös Loránd University, Budapest, Hungary. I obtained my PhD in Bioorganic Chemistry in 2018 at Eötvös Loránd University in the MTA-ELTE Research Group of Peptide Chemistry under the supervision of Dr. Szilvia Bősze. During my studies, I have broadened my research experience in several foreign institutions (Germany, Czech Republic, Peru, Japan). My PhD work involved the synthesis and biological evaluation of antimycobacterial agents and drug-peptide conjugates for targeted drug delivery. After my PhD I worked on the development of drug-peptide conjugates against glioblastoma in the same group.

I have joined the BioNanoSurf group (INMA – CSIC/UNIZAR, Zaragoza, Spain) in July 2019 as a Marie Skłodowska-Curie postdoctoral fellow (MSCA-IF ID: 842652, TBNANO) under the supervision of Dr. Jesús Martínez de la Fuente. The aim of the TBNANO project is the development of targeted intracellular delivery of antitubercular agents by functionalized nanocapsules. I continued this research line in the same group in the frame of the MSCA-IF – ERC extension by CSIC. This work was extended with the further development of the nanoparticles aiming to target granulomas in TB and to overcome other highly emerging bacterial infections and biofilm formation. I am currently working in the same group as a postdoctoral researcher in the frame of the EU H2020-funded, international Phoenix project, where my work focuses on the characterization of ligand functionalized liposomes and other nanostructures. I am also participating in a project studying the interaction between nanoparticles and biological barrier models.

timeline

CV

CURRENT POSITION
  
        Postdoctoral researcher at Bionanosurf group
        
        Instituto de Nanociencia y Materiales de Aragón (INMA)
        Consejo Superior de Investigaciones Científicas (CSIC)
        Universidad de Zaragoza

        Edificio I+D+i - Campus Río Ebro
        C/ Mariano Esquillor s/n 50018 Zaragoza (Spain)

        E-mail:
         zsuzsabaranyai AT unizar.es
         zsuzsa.baranyai AT csic.es
         baranyaizsuzs AT gmail.com 

        Web:
          http://zsuzsabaranyai.com
          http://bionanosurf.unizar.es/zsuzsa-baranyai
          https://inma.unizar-csic.es/investigadores/baranyai-zsuzsa-eva
          http://peptid.chem.elte.hu/baranyai_eng.html 
        
EDUCATION, QUALIFICATION

          2006-2009    BSc in Chemistry (Eötvös Loránd University (ELTE), Budapest, Hungary)
          2009-2011    MSc in Chemistry, Pharmaceutical Chemistry Module (ELTE, Budapest, Hungary)
          2011-2017    PhD in Chemistry (summa cum laude), Synthetic Chemistry,
          Materials Science and Biomolecular Chemistry Program 
          (MTA-ELTE Research Group of Peptide Chemistry, Budapest, Hungary)
        
SCIENTIFIC ACTIVITIES

        2005-2006 	University of Debrecen, Department of Inorganic and Analytical Chemistry (Debrecen, Hungary),
        participant of the Conference Series for Students (TUDOK) as a secondary school student
        supervisor: Dr. Gábor Lente
        project: Photochemical reaction of cerium(III) ion

        2007-2011 	MTA-ELTE Research Group of Peptide Chemistry, Science Conference for Students member,
         thesis projects
        supervisors: Dr. Szilvia Bősze, Dr. Kata Horváti
        BSc thesis: Selective targeting of antitubercular drugs to infected macrophages using peptide conjugates
         (2009)
        Science Conference for Students thesis: Synthesis and functional characterization of peptide conjugates 
        that inhibit the growth of Mycobacterium tuberculosis (2009)
        MSc thesis: Synthesis and functional characterization of compounds that inhibit the growth of 
        Mycobacterium tuberculosis (2011)

        2011-2017 	MTA-ELTE Research Group of Peptide Chemistry, PhD student, doctoral candidate
        supervisor: Dr. Szilvia Bősze
        PhD thesis: Synthesis and biological evaluation of antimycobacterial agents and conjugates (2017)

        2017- 2019 	MTA-ELTE Research Group of Peptide Chemistry, assistant research fellow
        supervisor: Dr. Szilvia Bősze
        projects: Antimycobacterial drug-peptide conjugates; Drug-peptide conjugates against glioblastoma in the 
        frame of the New National Excellence Program Fellowship (ÚNKP-17-3) and National Competitiveness and
         Excellence Programme (NVKP_16-1-2016-0036)

        2019-to date	Bionanosurf Group, Institute of Nanoscience and Materials of Aragon (INMA), Spanish 
        National Research Council (CSIC), University of Zaragoza, Marie Skłodowska-Curie fellow
        supervisor: Dr. Jesús Martínez de la Fuente 
        project: Targeted intracellular delivery of antitubercular agents by functionalized nanocapsules 
        (MSCA-IF ID: 842652, TBNANO, 01.07.2019-30.06.2021)

      
STUDY TRIPS

        2010 (3 months)	University of Konstanz, Department of Chemistry, Laboratory of Analytical Chemistry and 
        Biopolymer Structure Analysis (Konstanz, Germany)
        Erasmus Practical Placement Fellowship
        hosting scientist: Dr. Marilena Manea
        project: Synthesis and biochemical characterization of anticancer drug-peptide bioconjugates

        2011 (1 month)	Charles University in Prague, Faculty of Pharmacy, Department of Inorganic and Organic 
        Chemistry (Hradec Králové, Czech Republic)
        Fellowship of Pázmány-Eötvös Foundation for Natural Sciences and Informatics
        hosting scientist: Prof. Jarmila Vinšová
        project: Synthesis of salicylanilide derivatives as antimicrobial compounds

        2013 (1 month)	Charles University in Prague, Faculty of Pharmacy, Department of Inorganic and Organic 
        Chemistry (Hradec Králové, Czech Republic)
        Campus Hungary Short Term Study Program Fellowship
        hosting scientist: Prof. Jarmila Vinšová
        project: Synthesis of antimicrobial compounds that can be conjugated to peptides

        2014 (5 weeks)	Peruvian National Institute of Health, Laboratory of Molecular Biology and Immunology 
        (Lima, Peru)
        Campus Hungary Short Term Study Program Fellowship
        hosting scientist: Dr. Heinner Guio
        project: Development of peptide based synthetic antigens for the in vitro specific detection of latent 
        Mycobacterium tuberculosis infection

        2017 (10 days)	Kyoto University, Institute for Chemical Research, Division of Biochemistry, 
        Biofunctional Design Chemistry (Kyoto, Japan)
        Japanese-Hungarian Intergovernmental program (TÉT_12_JP-1- 2014-0023) 
        main investigator: Dr. Zoltán Bánóczi (MTA-ELTE Research Group of Peptide Chemistry)
        hosting scientist: Prof. Shiroh Futaki
        project: Evaluation of cell-penetrating peptides using confocal microscopy

        
AWARDS AND FELLOWSHIPS

        2009, 2010 	Bolyai Master’s Fellowship
        2009 		Science Conference for Students in Chemistry at Eötvös Loránd University, 3rd prize
        2010 		2nd Biology and Chemistry College Conference, Biochemistry Section, 1st prize
        2010 		Students in Research, Poster Section Special Award
        2010, 2011	Excellent Student of the Faculty Award, Eötvös Loránd University
        2010 		Erasmus Practical Placement Fellowship
        2010 		Hungarian National Scholarship
        2011 		Thesis Award, Hungarian Chemical Society
        2012, 2014	Campus Hungary Short Term Study Program Fellowship
        2014 		Gedeon Richter Centenary Foundation Fellowship
        2014		Travel grant for the 33rd European Peptide Symposium, Sofia, Bulgaria, 31.08.2014-05.09.2014
        2015		Microtrade Kft. Young Researchers Competition, 1st prize
        2017 		New National Excellence Program Fellowship (ÚNKP-17-3)
        2017 		Albert Szent-Györgyi Young Investigator Award of The New York Hungarian Scientific Society 
        (application video: https://youtu.be/WmbHifcGPFM)
        2018		MedInProt Mentor Pupil Program (Protein Science Research Synergy Program)
        2018		Travel grant for the RiminiPeptides2018 conference, Rimini, Italy, 16.06.2018-18.06.2018.
        2018		Publication Award of the Kisfaludy Lajos Foundation (1st prize for the paper Baranyai, Zs. et al,
         Eur. J. Med. Chem., 2017, 133, 152-173.)
        2019		Marie Skłodowska-Curie Actions Individual Fellowship (MSCA-IF ID: 842652, TBNANO)
        2021		CSIC extension of projects MSCA IF-ERC
        
LANGUAGE SKILLS

        •	Hungarian (native language)
        •	English intermediate language exam (2005)
        •	German intermediate language exam (2006)
        •	Spanish intermediate language exam (2017)
        
INTERESTS, HOBBIES

        photography, hiking, cycling, language learning
          

Research

Targeted intracellular delivery of antitubercular agents by functionalized nanocapsules
(MSCA-IF ID: 842652, TBNANO, 01.07.2019-30.06.2021)
The project focuses on the design, development and evaluation of antitubercular drug-loaded, functionalized nanocapsules capable of targeting host cells.
Targeted intracellular delivery of antitubercular agents by functionalized nanocapsules

Drug-peptide conjugates against glioblastoma
Targeted intracellular delivery of antitubercular agents by functionalized nanocapsules
Synthesis and biological evaluation of antimycobacterial agents and conjugates
Targeted intracellular delivery of antitubercular agents by functionalized nanocapsules

Publications

Horváth, L., Biri-Kovács, B., Baranyai, Z., Stipsicz, B., Méhes, E., Jezsó, B., Krátký, M., Vinšová, J., Bősze, S. New salicylanilide derivatives and their peptide conjugates as anticancer compounds: synthesis, characterization, and in vitro effect on glioblastoma, ACS Omega, 2024, in press.
Horváth, L.B., Krátký, M., Václav, P., Méhes, E., Gyulai, G., Kohut, G., Babiczky, Á., Biri-Kovács, B., Baranyai, Z., Vinšová, J., Bősze, S., Host cell targeting of novel antimycobacterial 4-aminosalicylic acid derivatives with tuftsin carrier peptides, Eur. J. Pharm. Biopharm., 2022, 174, 111-130.
Szabó, I., Illien, F., Dókus, L.E., Yousef, M., Baranyai, Zs., Bősze, Sz., Ise, S., Kawano, K., Sagan, S., Futaki, S., Hudecz, F., Bánóczi, Z., Influence of the Dabcyl group on the cellular uptake of cationic peptides: short oligoarginines as efficient cell-penetrating peptides, Amino Acids, 2021, 53, 1033-1049.
Baranyai, Zs., Biri-Kovács, B., Krátký, M., Szeder, B., Debreczeni, M.L., Budai, J., Kovács, B., Horváth, L., Pári, E., Németh, Zs., Cervenak, L., Zsila, F., Méhes, E., Kiss, É., Vinsova, J., Bősze, Sz., Cellular internalization and inhibition capacity of new anti-glioma peptide conjugates: physicochemical characterization and evaluation on various monolayer- and 3D-spheroid-based in vitro platforms, J. Med. Chem., 2021, 64, 2982-3005.
Baranyai, Zs., Soria‐Carrera, H., Alleva, M., Millán‐Placer, A.C., Lucía, A., Martín‐Rapún, R., Aínsa, J.A., de la Fuente, J.M., Nanotechnology‐based targeted drug delivery: an emerging tool to overcome tuberculosis, Adv. Ther., 2021, 4, 2000113.
Baranyai, Zs., Fighting against intracellular pathogens: host cell-targeted drug delivery, Future Microbiol., 2020, 15, 833-836.
Krátký, M., Baranyai, Zs., Štěpánková, Š., Svrčková, K., Švarcová, M., Stolaříková, J., Horváth, L., Bősze, Sz., Vinšová J., N-Alkyl-2-[4-(trifluoromethyl) benzoyl] hydrazine-1-carboxamides and their analogues: synthesis and multitarget biological activity, Molecules, 2020, 25, 2268.
Krátký, M., Janďourek, O., Baranyai, Zs., Novotná, E., Stolaříková, J., Bősze, Sz., Vinšová, J., Phenolic N-monosubstituted carbamates: Antitubercular and toxicity evaluation of multi-targeting compounds, Eur. J. Med. Chem., 2019, 181, 111578.
Baranyai, Zs., Krátký, M., Vosátka, R., Szabó, E., Senoner, Zs., Dávid, S., Stolaříková, J., Vinšová, J., Bősze, Sz., In vitro biological evaluation of new antimycobacterial salicylanilide-tuftsin conjugates, Eur. J. Med. Chem., 2017, 133, 152-173.
Krátký, M., Bősze, Sz., Baranyai, Zs., Stolaříková, J., Vinšová, J., Synthesis and biological evolution of hydrazones derived from 4-(trifluoromethyl)benzohydrazide, Bioorg. Med. Chem. Lett., 2017, 27, 5185-5189.
Ábrahám, Á.*, Baranyai, Zs.*, Gyulai, G., Pári, E., Horváti, K., Bősze, Sz., Kiss, É., Comparative analysis of new peptide conjugates of antitubercular drug candidates − model membrane and in vitro studies, Colloid. Surface. B., 2016, 147, 106-115. *equal contribution authorship
Baranyai, Zs., Krátký, M., Vinšová, J., Szabó, N., Senoner, Zs., Horváti, K., Stolaříková J., Dávid, S., Bősze, Sz., Combating highly resistant emerging pathogen Mycobacterium abscessus and Mycobacterium tuberculosis with novel salicylanilide esters and carbamates, Eur. J. Med. Chem., 2015, 101, 692-704.
Krátký, M., Bősze, Sz., Baranyai, Zs., Szabó, I., Stolaríková, J., Paraskevopoulos, G., Vinšová, J., Synthesis and in vitro biological evaluation of 2-(phenylcarbamoyl)phenyl 4-substituted benzoates, Bioorg. Med. Chem., 2015, 23, 868-875.
Cserép, G.*, Baranyai, Zs.*, Komáromy, D., Horváti, K., Bősze, Sz., Kele, P., Fluorogenic tagging of peptides via Cys residues using thiol-specific vinyl sulfone affinity tags, Tetrahedron, 2014, 70, 5961-5965. *equal contribution authorship
Manea, M., Leurs, U., Orbán, E., Baranyai, Zs., Öhlschläger, P., Marquardt, A., Schulcz, Á., Tejeda, M., Kapuvári, B., Tóvári, J., Mező, G., Enhanced enzymatic stability and antitumor activity of daunorubicin-GnRH-III bioconjugates modified in position 4, Bioconjug. Chem., 2011, 22, 1320-1329.
Lente, G., Kalmár, J., Baranyai, Zs., Kun, A., Kék, I., Bajusz, D., Takács, M., Veres, L., Fábián, I., One- versus two-electron oxidation with peroxomonosulfate ion: reactions with iron(II), vanadium(IV), halide ions, and photoreaction with cerium(III), Inorg. Chem., 2009, 48, 1763-1773.

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